Formulation Deep Dive
Perricone MD’s Cold Plasma Plus+ Sub-D/Neck is formulated as a high-performance corrective emulsion designed to target the structural integrity of the neck and jawline. The carrier system utilizes a sophisticated blend of hydrogenated polyisobutene, isononyl isononanoate, and glycerin, providing a structured yet spreadable base that balances emolliency with deep hydration. The active performance is driven by a synergistic complex of Dimethyl MEA (DMAE) for topical firming, Acetyl Carnitine HCL for cellular energy support, and Niacinamide (Vitamin B3) to improve skin barrier function and tone. This is further supported by Palmitoyl Tripeptide-5 to stimulate collagen synthesis and Glycolic Acid for gentle resurfacing. The formulation is stabilized through a robust polymer network including Xanthan Gum and Sclerotium Gum, and it is preserved with a system of Phenoxyethanol, Potassium Sorbate, and Sodium Benzoate to ensure the stability of the multifaceted active load.
Formula Structure Overview
This formula has a 74% match with ingredients from our research database. Among the matched ingredients, the main functional themes identified are categorized as barrier support, antioxidant, moisturizer, and emollient ingredients.
Reviewed Ingredient Coverage
74%
Water
GREAT
Purified water serves as the primary, high-quality solvent in most cosmetics.
Solvent
Hydrogenated Polyisobutene
GOOD
A stable synthetic emollient giving gloss, cushion and a protective, water-resistant film.
Emollient
Isononyl Isononanoate
NOT RATED
Glycerin
GREAT
To attract and retain moisture in the skin and hair, enhancing hydration and improving barrier function.
Hydrator
Moisturizer
Emollient
Texture Enhancer
Conditioner
Soother
Barrier Support
Anti-Aging Agent
Solvent
Propanediol
GREAT
Improve hydration, solubilize actives, enhance texture and absorption, support barrier function.
Hydrator
Emollient
Barrier Support
Solvent
Acetyl Carnitine HCL
NOT RATED
Cetearyl Alcohol
GOOD
Stabilize and thicken emulsions while depositing a soft, emollient film that improves skin feel and hair manageability.
Moisturizer
Emollient
Texture Enhancer
Conditioner
Barrier Support
Emulsifier
Niacinamide
GREAT
To enhance skin and scalp health by improving barrier function, reducing inflammation, and providing antioxidant protection.
Hydrator
Moisturizer
Antioxidant
Strengthener
Anti-Inflammatory Agent
Barrier Support
Oil Control Agent
Tone Evener
Anti-Aging Agent
Hydrogenated Vegetable Glycerides
NOT RATED
Dimethicone
GOOD
Forms a protective barrier, locks in moisture, smooths skin and hair texture, and enhances product application.
Moisturizer
Emollient
Texture Enhancer
Conditioner
Anti-Frizz Agent
Barrier Support
Glycolic Acid
GREAT
To exfoliate the skin and scalp, reduce signs of aging, treat acne, even skin tone, and improve scalp health and hair manageability.
Conditioner
Exfoliant
Tone Evener
Anti-Aging Agent
PEG-100 Stearate
NOT RATED
Glyceryl Stearate
GOOD
To stabilize oil and water mixtures, enhance product texture, moisturize skin, and condition hair in cosmetic formulations.
Emollient
Texture Enhancer
Conditioner
Emulsifier
Phosphatidylcholine
NOT RATED
Tetrahexyldecyl Ascorbate
GREAT
Deliver stable vitamin C activity to improve skin tone, stimulate collagen synthesis, and protect skin and hair from oxidative stress.
Antioxidant
Strengthener
Tone Evener
Anti-Aging Agent
Palmitoyl Tripeptide-5
GREAT
Stimulates collagen synthesis and inhibits collagen-degrading enzymes to improve skin firmness and reduce signs of aging.
Strengthener
Soother
Anti-Inflammatory Agent
Barrier Support
Tone Evener
Anti-Aging Agent
Xanthan Gum
GOOD
Improves formula viscosity and stability, enhances spreadability, supports skin hydration by forming a moisture-retaining film, and smooths hair appearance.
Hydrator
Moisturizer
Texture Enhancer
Conditioner
Soother
Barrier Support
Emulsifier
Echium Plantagineum Seed Oil
NOT RATED
Acetyl Tyrosine
NOT RATED
Squalane Oil
GREAT
To provide moisturization and enhance the skin and hair's barrier function.
Moisturizer
Emollient
Texture Enhancer
Antioxidant
Barrier Support
Phytic Acid
GOOD
A plant-derived chelating agent and mild antioxidant that stabilizes formulas and supports an even skin tone.
Chelating Agent
Antioxidant
Ethylhexylglycerin
GOOD
A multifunctional additive that boosts preservative efficacy, provides deodorant activity, and conditions skin with a light, non-greasy feel.
Preservative
Microbiome Balance Agent
Helianthus annuus (Sunflower) Seed Oil
GREAT
To reinforce skin barrier function, deliver lightweight hydration, and protect against oxidative stress—while improving texture and ease of application.
Moisturizer
Emollient
Texture Enhancer
Antioxidant
Soother
Barrier Support
Tocopherol (Vitamin E)
GREAT
To provide antioxidant protection, moisturize and condition the skin and hair, support the skin’s barrier function, soothe irritation, and protect against environmental damage.
Moisturizer
Emollient
Conditioner
Antioxidant
Soother
Barrier Support
Anti-Aging Agent
Soy Lecithin
GREAT
To stabilize emulsions, improve texture, support barrier integrity, boost hydration, and deliver actives effectively into skin and hair layers.
Moisturizer
Emollient
Texture Enhancer
Conditioner
Anti-Frizz Agent
Antioxidant
Barrier Support
Emulsifier
Zinc Gluconate
FAIR
To reduce sebum, calm inflammation, inhibit microbial activity, combat oxidative stress, and accelerate skin repair in both topical skincare and scalp treatments.
Astringent
Antioxidant
Anti-Inflammatory Agent
Barrier Support
Oil Control Agent
Preservative
Magnesium Aspartate
NOT RATED
Glycine Soja (Soybean) Oil
GOOD
To hydrate and condition skin and hair while supplying antioxidant support and enhancing barrier function.
Moisturizer
Emollient
Texture Enhancer
Conditioner
Antioxidant
Soother
Barrier Support
Oil Control Agent
Caffeine
GOOD
To reduce puffiness and dark circles, improve skin tone, and stimulate hair growth.
Antioxidant
Strengthener
Anti-Inflammatory Agent
Tone Evener
Anti-Aging Agent
Blood Flow Modulator
Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate
NOT RATED
Sodium Hyaluronate
GREAT
To attract and retain moisture within skin and hair-care formulations, improve product texture and spread, fortify barrier integrity and deliver a smoothing, plumping effect.
Hydrator
Moisturizer
Texture Enhancer
Conditioner
Soother
Barrier Support
Anti-Aging Agent
Palmitoyl Carnitine
NOT RATED
Copper Gluconate
NOT RATED
Carrageenan Gum
GOOD
To thicken and stabilize emulsions, form flexible films that lock in moisture, and provide viscosity and slip to skin‑care and hair‑care formulations.
Hydrator
Moisturizer
Emollient
Texture Enhancer
Conditioner
Antioxidant
Anti-Inflammatory Agent
Barrier Support
Emulsifier
Disodium EDTA
GOOD
To bind and deactivate metal ions, ensuring formula stability, consistency, and enhanced sensory and preservative performance in both skincare and haircare products.
Texture Enhancer
Cleansing Agent
Emulsifier
Preservative
Chelating Agent
HEA/Sodium Acryloyldimethyl Taurate Copolymer
GOOD
Serves as a cold-process rheology modifier, emulsifier and emulsion stabilizer — thickening, gelling and stabilizing water-based and oil-in-water systems while delivering a light, non-tacky skin feel.
Texture Enhancer
Emulsifier
Cetearyl Glucoside
GOOD
A gentle, naturally-derived sugar-based o/w emulsifier for soft, stable creams and lotions.
Emulsifier
Sclerotium Gum
GREAT
To thicken and stabilize aqueous systems, create a hydrating and smooth film on skin or hair, and improve overall sensory experience.
Hydrator
Moisturizer
Texture Enhancer
Caprylyl Glycol
GREAT
Enhances hydration, texture, and skin/hair conditioning while improving emulsion stability.
Hydrator
Moisturizer
Emollient
Texture Enhancer
Conditioner
Anti-Frizz Agent
Microbiome Balance Agent
Barrier Support
Emulsifier
Polysorbate 60
GOOD
A mild, nonionic oil-in-water emulsifier and solubilizer that binds oil and water into stable emulsions and disperses fragrance and oil-soluble actives into water-based formulas.
Emulsifier
Solvent
Phenoxyethanol
GOOD
A broad-spectrum cosmetic preservative that protects water-containing formulas against bacteria, yeast and mold.
Preservative
Potassium Sorbate
GOOD
Functions as a preservative (antimicrobial), protecting water-containing formulations primarily against yeasts and molds, with weaker activity against bacteria. Its activity is pH-dependent and strongest in acidic systems (effective below roughly pH 6, optimal near pH 4.4), so it is used in low-pH products and is commonly paired with a second preservative such as sodium benzoate for broad-spectrum coverage.
Preservative
Fragrance
FAIR
The aromatic component of a cosmetic — a blended scent that defines a product’s smell and sensory experience, used within IFRA safe-use limits and with required allergen declaration.
Silica
GOOD
To absorb excess oil and improve product texture, spreadability, and visual skin finish.
Texture Enhancer
Volume Control Agent
Exfoliant
Oil Control Agent
Titanium Dioxide
GREAT
Provides broad-spectrum UV protection and enhances product opacity.
Texture Enhancer
Barrier Support
Tone Evener
UV Protector
Iron Oxides
GOOD
Provide natural, stable pigmentation while offering an added layer of defense against HEV/blue light and contributing to visually even, radiant formulations.
Texture Enhancer
Antioxidant
Tone Evener
Sodium Benzoate
GOOD
Functions as a preservative (antimicrobial), protecting water-containing formulations from yeast, mold, and bacterial spoilage. Its activity is pH-dependent and strongest in acidic systems (optimal below roughly pH 5), so it is used in low-pH products and frequently paired with potassium sorbate for broader, more robust preservation.
Preservative
Benzyl Benzoate
CAUTION
A naturally-occurring faint balsamic aromatic ester (also used as a fragrance fixative and solvent), used as a fragrance component; listed individually as an EU-declared allergen when present above regulatory thresholds.
The information provided in this review is based on internal research and publicly available sources. It is intended for general informational purposes only and does not constitute medical, legal, or regulatory advice. We do not guarantee the accuracy or completeness of this information. Users are encouraged to conduct their own research and consult appropriate professionals before making decisions based on this information.
