The Beauty & Personal Care Brand Builder Series

The Beauty & Personal Care Brand Builder Series

Copper Amino Isolate Serum 3 1:1 (CAIS3) | Manufacturing and Formulation Insights

This page provides an ingredient-level review of Copper Amino Isolate Serum 3 1:1 (CAIS3) by NIOD. Below you’ll find the publicly available ingredient list, a dynamic ingredient breakdown linked to the FormuNova ingredient database, and a formula structure overview intended for cosmetic founders, product developers, and brand teams researching competitor product architecture in modern face serums and related Beauty & Personal Care categories. This page is a formulation and manufacturing review and does not imply or state any association between FormuNova and NIOD.

Full Ingredient List

Aqua (Water), Glycerin, Tripeptide-29, Copper Tripeptide-1, Tripeptide-1, Myristoyl Nonapeptide-3, Trifluoroacetyl Tripeptide-2, Acetyl Tetrapeptide-2, Sodium Hyaluronate Crosspolymer, Glycogen, Propanediol, Pentylene Glycol, Dextran, Dimethyl Isosorbide, Ethoxydiglycol, Isoceteth-20, Leuconostoc/Radish Root Ferment Filtrate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin

Formulation Deep Dive

Copper Amino Isolate Serum 3 1:1 (CAIS3) by NIOD is engineered as a water-based, peptide-forward serum built around a high concentration of copper peptide and a broad supporting peptide architecture. The carrier is a streamlined aqueous system of Aqua and Glycerin, with Glycerin doubling as the primary humectant. The formula's defining feature is its position high in the ingredient list for Copper Tripeptide-1, paired with a layered peptide complex of Tripeptide-29, Tripeptide-1, Myristoyl Nonapeptide-3, Trifluoroacetyl Tripeptide-2, and Acetyl Tetrapeptide-2 to diversify the signaling profile. Hydration and substantivity are reinforced by Sodium Hyaluronate Crosspolymer for a cushioned, film-forming moisture layer, while Glycogen and Dextran act as biopolymer conditioning agents that support skin feel and texture. A solvent and penetration-modifier system of Propanediol, Pentylene Glycol, Dimethyl Isosorbide, and Ethoxydiglycol keeps the actives soluble and aids even spreadability, with Isoceteth-20 serving as a solubilizer for any sparingly water-soluble components. The result is a lightweight, fast-absorbing fluid with no oils or silicones. Preservation follows a hybrid clean-label strategy combining Leuconostoc/Radish Root Ferment Filtrate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, and Chlorphenesin.

Formula Structure Overview

This formula has a 81% match with ingredients from our research database. Among the matched ingredients, the main functional themes identified are categorized as barrier support, anti-aging agent, hydrator, and strengthener ingredients.

Reviewed Ingredient Coverage
81%
Matched Ingredients
17

Ingredient Analysis

About our ratings
Water GREAT
Purified water serves as the primary, high-quality solvent in most cosmetics.
Solvent
Glycerin GREAT
To attract and retain moisture in the skin and hair, enhancing hydration and improving barrier function.
Hydrator Moisturizer Emollient Texture Enhancer Conditioner Soother Barrier Support Anti-Aging Agent Solvent
Tripeptide-29 FAIR
To stimulate type I collagen synthesis, improve dermal matrix integrity and moisture retention, and strengthen hair fibres by mimicking collagen fragments.
Anti-Frizz Agent Volume Control Agent Antioxidant Strengthener Anti-Inflammatory Agent Barrier Support Anti-Aging Agent
GHK-Cu GREAT
To stimulate collagen production, enhance skin elasticity, reduce signs of aging, and promote hair growth.
Antioxidant Strengthener Anti-Inflammatory Agent Barrier Support Tone Evener Anti-Aging Agent Blood Flow Modulator
Tripeptide-1 GREAT
The copper-free GHK signal peptide, used to support the appearance of firm, smooth, renewed skin.
Anti-Aging Agent Strengthener
Myristoyl Nonapeptide-3 NOT RATED
Trifluoroacetyl Tripeptide-2 NOT RATED
Acetyl Tetrapeptide-2 GOOD
A signal peptide used to support the appearance of firmer, more elastic-looking skin.
Anti-Aging Agent
Hyaluronic Acid Crosspolymer GREAT
Provide deep and sustained hydration; enhance skin barrier function; improve skin texture and elasticity.
Hydrator Moisturizer Texture Enhancer Barrier Support Anti-Aging Agent
Glycogen NOT RATED
Propanediol GREAT
Improve hydration, solubilize actives, enhance texture and absorption, support barrier function.
Hydrator Emollient Barrier Support Solvent
Pentylene Glycol GREAT
To elevate cosmetic formulations by delivering efficient hydration, actives solubilization, enhanced texture, and supplemental antimicrobial support—thereby improving both performance and sensory quality.
Hydrator Moisturizer Texture Enhancer Conditioner Soother Barrier Support Solvent Preservative
Dextran GOOD
A naturally derived polysaccharide used as a skin-conditioning humectant, texture / viscosity modifier and gentle carrier.
Hydrator Texture Enhancer
Dimethyl Isosorbide GOOD
A powerful solvent and penetration enhancer that dissolves and delivers difficult actives.
Solvent
Ethoxydiglycol GOOD
A high-performance solvent and penetration enhancer for hard-to-dissolve actives.
Solvent
Isoceteth-20 NOT RATED
Leuconostoc/Radish Root Ferment Filtrate GOOD
A naturally derived, fermentation-based antimicrobial used for clean-beauty preservation.
Preservative
Caprylyl Glycol GREAT
Enhances hydration, texture, and skin/hair conditioning while improving emulsion stability.
Hydrator Moisturizer Emollient Texture Enhancer Conditioner Anti-Frizz Agent Microbiome Balance Agent Barrier Support Emulsifier
Ethylhexylglycerin GOOD
A multifunctional additive that boosts preservative efficacy, provides deodorant activity, and conditions skin with a light, non-greasy feel.
Preservative Microbiome Balance Agent
Phenoxyethanol GOOD
A broad-spectrum cosmetic preservative that protects water-containing formulas against bacteria, yeast and mold.
Preservative
Chlorphenesin GOOD
A mild, stable cosmetic preservative used to broaden and reinforce a preservative system.
Preservative
The information provided in this review is based on internal research and publicly available sources. It is intended for general informational purposes only and does not constitute medical, legal, or regulatory advice. We do not guarantee the accuracy or completeness of this information. Users are encouraged to conduct their own research and consult appropriate professionals before making decisions based on this information.

The manufacturing partners for NIOD are not publicly disclosed. Many brands work with multiple contract manufacturers across different regions depending on production volume, product type, and regulatory requirements.

Exact sales numbers for NIOD are not publicly disclosed.

NIOD has successfully captured market share by focusing on a successful balance of marketing and formulation.

Replicating that success requires more than just copying a formula, it requires identifying a marketing strategy that is unique to your brand’s audience, associated with a great product offering.

At FormuNova, we specialize in helping brands move past imitation to create high-performance product offerings with potential to outperform the current market leaders. Let’s discuss your launch strategy.

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Made in USA
Made in USA
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