Benefits of sh-Oligopeptide-2

A premium, biotech-derived growth-factor active used to support the appearance of renewed skin and healthy hair.

• Renewal Appearance: Promotes cell proliferation and survival in laboratory studies — supporting a renewed, revitalized look.
• EGF Synergy: Research shows IGF-1 and EGF act in synergy on keratinocytes, a basis for pairing them in complexes.
• Hair-Cycle Relevance: IGF-1 is a recognized signal in the anagen (growth) phase of the hair follicle, so it is popular in scalp serums (for the look of healthy hair).
• Premium Biotech Active: A recombinant “synthetic human” peptide made by fermentation.

How It Works

sh-Oligopeptide-2 is a recombinant analog of IGF-1. It binds the IGF receptor to promote cell proliferation and survival; published work shows synergy with EGF on keratinocytes, and IGF-1 is a known signal in the anagen (growth) phase of the hair cycle. As with all large growth-factor proteins, penetration through intact skin is inherently limited, so stabilization and delivery are the real formulation challenge and topical efficacy continues to be studied — this is an active, biologically-grounded ingredient, not a finished product claim.

Formulating with sh-Oligopeptide-2

Used at very low levels in the water / cool-down phase of serums and essences, typically as part of a growth-factor complex. It is heat- and shear-sensitive, so add it late and keep it cool; prioritize a stabilizing, delivery-focused system and confirm compatibility and preservation in the finished formula.