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The Beauty & Personal Care Brand Builder Series

Ingredient Deep Dive

Cetyl Hydroxyproline Palmitamide

The Beauty & Personal Care Brand Builder Series

Ingredient Deep Dive

Cetyl Hydroxyproline Palmitamide

A Skin-Barrier Pseudo-Ceramide

Cetyl Hydroxyproline Palmitamide — known commercially as Ceramide CPP — is a synthetic ceramide-like lipid (a pseudo-ceramide) built on a hydroxyproline backbone.

It mimics the skin’s own ceramides to help reinforce the moisture barrier, reduce the look of dryness, and give creams a conditioned, replenished feel.

Quick Insights

Ingredient Rating:

GOOD

Type of Ingredient:

Barrier Support and Emollient

Intended Function:

A ceramide-like pseudo-ceramide lipid that helps reinforce the skin’s moisture barrier and reduce the look of dryness.

Common Applications:

Used in barrier-repair and ceramide moisturizers and creams.

Target Audience:

Brands building barrier-repair, ceramide or sensitive-skin moisturizers.

Also Known As:

Cetyl Hydroxyproline Palmitamide (Ceramide CPP)

Benefits of Cetyl Hydroxyproline Palmitamide

A dependable functional ingredient that does its job elegantly.

Barrier Support: Ceramide-mimicking lipid that helps reinforce the skin’s moisture barrier.
Reduces Dryness Look: Supports a smoother, less dry, replenished appearance.
Skin-Identical Feel: Integrates into the surface lipids for a conditioned feel.
Emollient: Softens and smooths the skin surface.
Formulation-Friendly: A stable pseudo-ceramide for barrier creams.

How It Works

The skin barrier depends on ceramides packed between corneocytes; Cetyl Hydroxyproline Palmitamide is a pseudo-ceramide designed to slot into that lipid matrix, helping reinforce the barrier and reduce moisture loss — the basis of its use in ceramide and barrier-repair creams. As with topical lipids generally, it supports the barrier’s appearance and feel rather than acting as a drug.

Formulating with Cetyl Hydroxyproline Palmitamide

Oil-phase; incorporate with the lipids/emulsifiers per supplier guidance, typically alongside other barrier lipids (ceramides, cholesterol, fatty acids).

Safety Analysis

Cetyl Hydroxyproline Palmitamide is a well-tolerated, skin-compatible barrier lipid. Substantiate the finished product (patch / HRIPT) per MoCRA.

References

https://cosmetics.specialchem.com/inci-ingredients/cetyl-hydroxyproline-palmitam…

https://cosmeticanalysis.com/cosmetic-ingredients/cetyl-hydroxyproline-palmitami…

https://cosmileeurope.eu/inci/detail/2038/cetyl-hydroxyproline-palmitamide/

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