The Beauty & Personal Care Brand Builder Series

Ingredient Deep Dive

Acetyl Glutamine

The Beauty & Personal Care Brand Builder Series

Ingredient Deep Dive

Acetyl Glutamine

The Moisturizing Amino Acid

Acetyl Glutamine is a stabilized amino acid — an acetylated form of glutamine that skin recognizes as one of its own building blocks.

As a component of the skin’s natural moisturizing factor, it helps hydrate, condition and support a soft, supple, comfortable-feeling surface.

Quick Insights

Ingredient Rating:

GOOD

Type of Ingredient:

Hydrator and Conditioner

Intended Function:

A skin-identical amino acid used to hydrate, condition and soften the look and feel of skin.

Common Applications:

Used in serums and masks and night creams and moisturizers.

Target Audience:

Brands building hydrating, barrier-support and comfort-focused skin care.

Also Known As:

Acetyl Glutamine, N-Acetyl-L-Glutamine

Benefits of Acetyl Glutamine

A skin-identical amino acid used to hydrate, condition and support a soft, supple surface.

Hydration: Helps skin draw and hold moisture for a supple look.
NMF Support: A natural-moisturizing-factor amino acid the skin recognizes.
Conditioning: Leaves skin feeling soft, smooth and comfortable.
Barrier Comfort: Supports a calm, comfortable-feeling surface.
Gentle: A skin-identical building block, well tolerated by most skin.

How It Works

Amino acids are the building blocks of skin proteins and key components of its natural moisturizing factor; the acetyl group stabilizes glutamine for cosmetic use. Applied topically, it helps hydrate and condition, so skin looks and feels softer, smoother and more supple.

Formulating with Acetyl Glutamine

Acetyl Glutamine is water-soluble and added to the water phase, typically at cool-down and at low levels. It pairs well with other humectants and actives. Observe good manufacturing and preservation practice.

Safety Analysis

Acetyl Glutamine is well tolerated with an excellent skin-compatibility profile at cosmetic use levels. As always, substantiate the finished product’s safety (e.g. patch / HRIPT testing) in line with MoCRA requirements.

References

https://incidecoder.com/ingredients/acetyl-glutamine

https://cosmeticanalysis.com/cosmetic-ingredients/acetyl-glutamine

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