Urtica dioica root extract, derived from the taproot of the stinging nettle plant, delivers a spectrum of bioactive phytochemicals — including flavonoids, phenolic acids, vitamins, minerals, and sterols — that collectively provide potent antioxidant and anti-inflammatory benefits in topical formulations. Its astringent and sebum-regulating action is particularly useful in skincare targeted at oily or acne-prone skin, where it mitigates pore congestion and moderates excessive oil production by inhibiting the enzyme 5α-reductase and reducing pro-inflammatory cytokine signaling. Moreover, nettle’s antioxidant content protects the extracellular matrix from oxidative stress-induced degradation, supporting skin resilience and reducing visible signs of aging.

In haircare, Urtica dioica root extract demonstrates promising effects on follicular health. In ex vivo organ culture studies, ethanol extracts stimulated hair shaft elongation, decreased catagen (regression) phase transition, and enhanced proliferation of hair matrix keratinocytes, evidenced by increased Ki‑67 expression. Complementary claims suggest it may improve scalp microcirculation and deliver essential micronutrients to follicles, potentially reinforcing root structure, though broader human trials remain limited.