Saccharide Isomerate, a 100% plant-derived carbohydrate complex typically sourced from isomerized D-glucose of corn or sugarcane, is a highly effective moisturizing agent in skincare formulations. Structurally similar to the skin’s natural moisturizing factor, it binds to keratinocytes in the stratum corneum, forming a moisture reservoir that delivers hydration for up to 72 hours, even after washing. Its anti-inflammatory properties soothe erythema and irritation, making it ideal for sensitive, dry, or mature skin. The ingredient’s small molecular size enhances penetration, complementing hyaluronic acid to reduce fine lines and improve skin elasticity, positioning it as a key component in premium moisturizers, serums, and creams.
In haircare, Saccharide Isomerate excels as a hydrating and conditioning agent, particularly for addressing scalp conditions like dandruff and oiliness. Its ability to bind to keratin in hair and scalp tissues provides prolonged moisture, reducing flaking and improving scalp barrier function, as evidenced by a placebo-controlled study showing significant reductions in TEWL and sebum levels over 28 days. By rebalancing the scalp microbiome and mitigating dysbiosis associated with Malassezia species, it supports healthier hair growth and enhances strand manageability. Its gentle, non-irritating nature makes it suitable for shampoos, conditioners, and scalp treatments, offering brand owners a versatile ingredient for high-efficacy haircare formulations.

Quick Insights
Ingredient Rating:
GREAT
Type of Ingredient:
Hydrator, Moisturizer, Conditioner, Soother, Anti-Inflammatory Agent, Microbiome Balance Agent and Barrier Support
Intended Function:
Saccharide Isomerate provides long-lasting hydration, strengthens skin and scalp barriers, soothes irritation, and balances the microbiome.
Common Applications:
Used in moisturizers, serums, creams, shampoos, conditioners, scalp treatments, and masks.
Target Audience:
Consumers with dry, sensitive, or mature skin, or those with dandruff, oily scalps, or dry hair.
Also Known As:
Pentavitin, Waterin, Saccharomyces cerevisiae Extract.
Safety Analysis
Saccharide Isomerate is widely regarded as safe for cosmetic use, with a low risk of irritation or sensitization, as confirmed by safety assessments from the Environmental Working Group (EWG) and Cosmetic Ingredient Review. Formulators should ensure compatibility with other actives to avoid potential interactions in complex formulations.

References
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