Myristoyl Pentapeptide-17 is a synthetic lipo-oligopeptide composed of a five-amino acid sequence (Lys-Leu-Ala-Lys-Lys) conjugated with myristic acid, enhancing its lipophilicity and facilitating transdermal delivery. This peptide is renowned for its ability to upregulate keratin gene expression, a pivotal structural protein in hair and skin, thereby promoting the proliferation and fortification of hair follicles. Clinical assessments have demonstrated that formulations containing Myristoyl Pentapeptide-17 can augment the anagen (growth) phase of hair follicles, leading to increased hair density and thickness, particularly in eyelashes and eyebrows.
In skincare applications, Myristoyl Pentapeptide-17 exhibits anti-inflammatory and antimicrobial properties. It modulates pro-inflammatory cytokines, thereby alleviating skin irritation and inflammation. Additionally, its antimicrobial activity against pathogens such as Cutibacterium acnes and certain fungi contributes to a balanced skin microbiome. These attributes make it a valuable ingredient in formulations aimed at enhancing skin barrier function and overall skin health.

Quick Insights
Ingredient Rating:
GREAT
Type of Ingredient:
Strengthener, Soother, Anti-Inflammatory Agent, Microbiome Balance Agent, Barrier Support and Anti-Aging Agent
Intended Function:
Stimulates keratin gene expression to promote hair follicle proliferation and fortification, while enhancing skin barrier integrity and reducing inflammation.
Common Applications:
Eyelash and eyebrow growth serums, hair thickening treatments, anti-aging skincare products, soothing creams for sensitive skin, products targeting skin barrier repair.
Target Audience:
Individuals seeking solutions for thinning hair or eyelashes, consumers with sensitive or inflamed skin, and those interested in anti-aging skincare products.
Also Known As:
SymPeptide® 226EL, Myr-KLAKK-NH₂.
Safety Analysis
Comprehensive safety evaluations have been conducted on Myristoyl Pentapeptide-17. Clinical studies report no adverse effects, with the peptide being non-irritating and non-sensitizing even at concentrations up to 0.1% in cosmetic formulations. The Environmental Working Group (EWG) rates it with low concern for cancer, allergies, immunotoxicity, and developmental or reproductive toxicity. Additionally, it is not a prostaglandin analog, thereby avoiding associated side effects such as iris pigmentation changes or periorbital fat loss.

References
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