Palmitoyl Tripeptide-5 is a synthetic peptide composed of three amino acids—lysine, valine, and lysine—linked to a palmitic acid chain. This structure enhances its lipophilicity, facilitating deeper penetration into the skin layers. Once absorbed, it stimulates the production of Transforming Growth Factor-beta (TGF-β), a key regulator in collagen synthesis. By promoting collagen production, Palmitoyl Tripeptide-5 helps improve skin firmness, elasticity, and overall texture, making it a valuable ingredient in anti-aging skincare formulations.

In addition to its collagen-boosting properties, Palmitoyl Tripeptide-5 has been shown to inhibit matrix metalloproteinases (MMPs), enzymes that degrade collagen and other extracellular matrix components. This dual action not only promotes new collagen formation but also protects existing collagen from degradation. Furthermore, its ability to modulate inflammatory responses contributes to reduced skin redness and irritation, enhancing its suitability for sensitive skin applications.